Alagille Syndrome Market Report gives readers a thorough assessment of key market drivers, restraints, prospects, opportunities, restraints, current trends, and technological and industrial breakthroughs that will influence market growth. The detailed market research, industry sector growth and development, and new product introductions covered in this report on the Alagille Syndrome Market are of great assistance to the important new commercial players joining the market.
This Alagille Syndrome Market report research conducts a careful market evaluation and provides a professional analysis of the industry taking into account market development, present market circumstances, and forecasts for the future. The market driving factors, market overview, industry volume, and market share are also highlighted in this Alagille Syndrome Market report analysis.
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Alagille Syndrome: An Overview
Alagille Syndrome (ALGS) is a multisystem autosomal dominant disorder with a wide variety of clinical manifestations. It is also known as arteriohepatic dysplasia, Alagille-Watson syndrome, Watson-Miller syndrome or syndromic bile duct paucity. The clinical manifestations are variable, even within the same family, and commonly include hepatic (cholestasis, characterized by bile duct paucity on liver biopsy), cardiac (primarily involving the pulmonary arteries), renal skeletal (butterfly vertebrae), ophthalmologic (posterior embryotoxon), and facial abnormalities. It can range from a subclinical presentation to a life-threatening condition, with a mortality rate upto 10%.
Key highlights of the Alagille Syndrome Market Report
Alagille Syndrome Epidemiology Insights
The offspring of a patient with Alagille syndrome has a 50% chance of inheriting a gene mutation, whereas, among those affected with Alagille syndrome, 50% to 70% of individuals have a mutation de novo. No correlation has been found between a specific mutation and expressed phenotype. In more than 90 percent of cases, mutations in the JAG1 gene cause Alagille syndrome.
Alagille Syndrome Epidemiology Segmentation in the 7MM
Alagille Syndrome Treatment Market
Management of the disorder is aimed at preventing complications, increasing the flow of bile from the liver, maintaining normal growth and development and reducing blood cholesterol levels. Medicine may be used to increase bile flow and to relieve severe itching caused by buildup of bile in the blood and skin. These same medicines may be used to treat high cholesterol levels that cause the hard, whitish nodules that develop in the skin of patients with ALGS.
Alagille Syndrome Market Insights
Alagille syndrome is a rare genetic disorder that can affect multiple organ systems of the body including the liver, heart, skeleton, eyes and kidneys. The specific symptoms and severity of ALGS can vary greatly from one person to another, even within the same family. Some individuals may have mild forms of the disorder while others may have more serious forms.
Alagille Syndrome Market Forecast
Some affected infants and children with ALGS who do not respond to pharmacologic and dietary therapies may be treated by a surgical procedure known as partial biliary diversion. This surgical procedure is used to disrupt or divert recirculation of bile acids between the liver and the gastrointestinal tract.
Alagille Syndrome Market Size
The market size shall grow during the forecast period owing to the launch of upcoming therapies. The market size is expected to increase during the study period. Expected launch of the upcoming therapies shall fuel the growth of the market during the forecast period, i.e., 2022–2032
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Alagille Syndrome Market Report Highlights
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